Jane and Richard Thomas Center for Down Syndrome Services
- Cincinnati Children's Hospital Medical Center offers innovative approaches to caring for children with Down Syndrome.
- http://www.cincinnatichildrens.org/svc/alpha/d/disabilities/clinical/down-syndrome-center.htm

National Down Syndrome Society
- Not-for-profit organization supporting research in the United States. Includes details of education and advocacy programs.
- http://www.ndss.org

Riverbend Down Syndrome Parent Support Group
- Resources and abstracts for parents and professionals on communication, early intervention, therapies, medicine, literacy, medical issues, mathematics, vitamins and other supplements.
- http://www.altonweb.com/cs/downsyndrome/

DSAOC- Down Syndrome Association of Orange County
- Down Syndrome Association of Orange County, based in Santa Ana, California.
- http://www.dsaoc.org

Down Syndrome Association of NSW Australia
- Articles, newsletters, stories & photos for people with Down syndrome, their families, friends, educators and health care professionals.
- http://www.dsansw.org.au/

Connecticut Down Syndrome Congress
- Dedicated to improving the lives of persons with Down syndrome. Includes information on scholarships, and resources.
- http://www.ctdownsyndrome.org

Northern New England Down Syndrome Congress
- Non-profit organization of families, professionals, and others who are interested in sharing knowledge and the experience of Down Syndrome.
- http://nnedsc.org

North Country Down Syndrome Association
- Provides information about the association, which is located in Plattsburgh, NY, serving Clinton and Essex Counties. Also has pictures.
- http://ncdsasite.org

Central Illinois Down Syndrome Organization (CIDSO)
- Contains a list of the organization's goals, and information about their library and events.
- http://www.cidso.org/

Hawkeye Area Down Syndrome Association
- The organizations' goals, and also how to get on the MR Waiver List.
- http://www.hadsa.org

Mile High Down Syndrome Association
- Has a section on research, as well as examples of the Kids 'R Kids calendar.
- http://www.mhdsa.org

Down Syndrome Catalana Foundation
- Information about the foundation.
- http://www.fcsd.org/eng/index.htm

Sharing Down Syndrome Arizona
- Has a listing of Down Syndrome events in their area, also many poems and stories.
- http://sharingds.org/

Association of Greater Cincinnati for Down Syndrome
- Information on the programs they offer, and upcoming events.
- http://www.dsagc.com/

Down Syndrome Research Foundation
- Information on the Antioxidant Research Project and raising funds for it. Includes news, health issues, research, events, education, alternate therapies and contact details.
- http://www.dsrf.co.uk

Colorado Springs Down Syndrome Association
- Information about the organization as well as the disease. Includes membership, events, a photo album, articles and links.
- http://www.csdsa.org

The Down Syndrome Educational Trust
- Based in the United Kingdom. Working to advance the development and education of individuals with Down syndrome
- http://www.downsed.org/

Down Syndrome Research Online Advocacy Group
- Information on clinical, biomedical, and scientific research into Down syndrome.
- http://www.dsresearch.org

Down Syndrome Research Foundation and Resource Centre
- Articles on psychological, social, and physical development, also on health issues. Research project reports and summaries.
- http://www.dsrf.org

Down Syndrome Association of Toronto
- Information on education and health as it relates to Down Syndrome.
- http://dsat.ca/

National Association for Down Syndrome
- In Chicago. Includes a bulletin board.
- http://www.nads.org