American Civil Liberties Union of Western North Carolina
- Regional chapter of the ACLU. Features local action, meetings, college chapters. Based in Asheville.
- http://www.acluwnc.org/

WNC for Ron Paul
- Promotes the presidential candidate across the region. Presents article archives, forum, news.
- http://www.ronpaulwnc.com/

Mountain Area Red Cross
- Provides volunteer disaster services, blood collection and emergency assistance to western North Carolina.
- http://www.redcrosswnc.org/

District 29 Guardian ad Litem
- Provides a volunteer advocate for abused and neglected children in Henderson, Transylvania, Rutheford, McDowell and Polk Counties. Volunteer, news, statistics, and photo gallery.
- http://www.galdistrict29ab.org/

Western North Carolina Peace Coalition
- A coalition of groups that are promoting nonviolent solutions to world conflicts. Membership is open to all individuals and organizations in WNC.
- http://main.nc.us/wncpc/

Blue Ridge National Heritage Area
- Designated by Congress in 2003, the project celebrates the cultural history of the state's mountain area. Features regional crafts, music and agriculture plus national treasures.
- http://www.blueridgeheritage.com/

Alzheimer's Association of Western North Carolina
- Support, education, advocacy, and research for people with this condition. Information on the disease, programs and contact information.
- http://www.alz-nc.org/

Daniel Boone Council, Boy Scouts of America
- Information on programs and activities for Scout council which covers most of Western North Carolina.
- http://www.danielboonecouncil.org/

WNC Atheists
- Community of people who profess no belief in god(s). Features constitution, membership information, news, online forum.
- http://www.wncatheists.com/

Friends Of Mountain History
- Provides advocacy, educational support, and financial assistance to preserves the historical and cultural heritage of 24 western counties. Features goals, grants, programs, news.
- http://www.fomhnc.org

Valley River Humane Society
- Organization serving Clay, Graham, and Swain Counties. Calendar of events, pictures of pets available for adoption, and contact information.
- http://www.valleyriverhumanesociety.org/

YMCA of Western North Carolina
- Builds strong kids, strong families, strong communities.
- http://www.ymcawnc.org/

Community Foundation of Western North Carolina
- Creating a pool of charitable capital available for the eighteen western counties of the state. Information for advisors, donors, grants, and scholarships.
- http://www.cfwnc.org/

North Carolina Bartram Trail Society
- Official site of the society that maintains a 100-mile memorial trail walked by botanist William Bartram in 1775.
- http://www.ncbartramtrail.org/

Western Office of the Division of Archives and History
- Branch of the Office of Archives and History-Department of Cultural Resources, offering professional expertise in historic resource management. Information on programs and services.
- http://www.ah.dcr.state.nc.us/sections/wo/default.htm

The Episcopal Diocese of Western North Carolina
- Information on Diocese, programs and ministries, and member churches.
- http://www.diocesewnc.org/

Mountain Heritage Center
- Celebrates the natural and cultural heritage of the southern Appalachian region. The MHC is at Western Carolina University, Cullowhee.
- http://www.wcu.edu/mhc/