Cayman National Cultural Foundation
- Aimed to stimulate, facilitate and preserve cultural and artistic expression generally, particularly the preservation and exploration of Caymanian performing, visual and literary arts.
- http://www.artscayman.org/

National Trust for the Cayman Islands
- A non-profit organization with the mission of preserving natural environments and places of historic significance in the Cayman Islands for present and future generations.
- http://www.nationaltrust.org.ky/

The National Council of Voluntary Organisations
- An independent, non-profit, charitable organization that engages in projects to meet the ever-increasing social needs of the community.
- http://www.ncvo.org.ky/

Cayman Loves Children
- Dedicated to raise funds for children aid.
- http://caymanloveschildren.8k.com/

Cayman Islands Cancer Society
- Committed to educating the Cayman Islands and thus making the public aware of cancer as a major health problem. Aims to help in the prevention of cancer, and diminishing suffering through education, advocacy, and service.
- http://caymanislandscancersociety.org.ky/