PyGTK
- Python bindings for the GTK widget set. [Open Source, LGPL]
- http://www.pygtk.org//

pygame
- A set of Python extension modules designed for writing games. The core of pygame is wrapped on top of the SDL library. [Open Source, LGPL]
- http://pygame.seul.org/

The Dabo Framework
- A 3-tier, cross-platform application development framework, written in Python atop the wxPython GUI toolkit. [Open source, MIT license]
- http://dabodev.com/

xdialog
- A wrapper for the Xdialog program that encapsulates the details of calling Xdialog and getting return values. [Open Source, LGPL]
- http://www.chrisarndt.de/en/software/python/#xdialog

PyKDE
- Python bindings for the KDE desktop environment. [Open Source, BSD-like]
- http://www.riverbankcomputing.co.uk/pykde/index.php

PyQt
- Contains Python bindings for the Qt GUI toolkit. [Open Source, BSD-like]
- http://www.riverbankcomputing.co.uk/pyqt/index.php

PythonCard
- A software construction kit built in, and using, Python. Its purpose is to allow you to easily and quickly build graphical applications. [Open Source, Python license]
- http://pythoncard.sourceforge.net/

Python X Library
- Pure Python interface to X Window system. [Open Source, GPL]
- http://python-xlib.sourceforge.net/

Pmw
- Python meta widgets is a toolkit for building high-level compound widgets in Python using the Tkinter module. [Open Source, MIT license]
- http://pmw.sourceforge.net/

Tix Applications Framework
- Tixapps applications are a suite of development applications that run with Tk/Tcl or Python using the Tix widget set. Applications currently included are: tixinspect - an inspector for Tix/Tk applications; tixdebug - a debugger to work with tixinspect; a
- http://tix.sourceforge.net/Tixapps/

Tix
- The Tk Interface eXtension is a set of GUI components that enhance the appearance and functionality of your Tkinter applications. [Open Source, BSD-like]
- http://tix.sourceforge.net/

wxPython
- A popular cross-platform Python GUI toolkit for Windows and Unix with native look and feel on each platform. [Open Source, LGPL]
- http://www.wxpython.org/

FXPy
- Provides an interface to the FOX GUI library. [Open Source, LGPL]
- http://fxpy.sourceforge.net/

anygui
- The goal of this project is to create an easy-to-use, simple, and generic module for making graphical user interfaces in Python. [Open Source, MIT license]
- http://sourceforge.net/projects/anygui