Winpdb
- An advanced python debugger, with support for smart breakpoints, multiple threads, namespace modification, embedded debugging and encrypted communication.
- http://www.digitalpeers.com/pythondebugger/

Tixapps Applications Framework
- Tixapps applications are a suite of development applications that run with Tk/Tcl or Python, using the Tix widget set. [Open Source, BSD-like]
- http://tix.sourceforge.net/Tixapps/

Pymerase
- A tool intended to generate a python object model, relational database, and an object-relational model connecting the two using UML or XML. However, it has been extended to also output GUI widgets and can be easily extended to output whatever else you mig
- http://pymerase.sourceforge.net/

PyCrust - The Flakiest Python Shell
- An interactive, graphical Python shell written in Python using wxPython.
- http://sourceforge.net/projects/pycrust/

IPython
- An enhanced interactive Python shell with many features for object introspection, system shell access, and its own special command system for adding functionality when working interactively. [Open Source, LGPL]
- http://ipython.scipy.org/

Hap Python Remote Debugger
- A remote debugger and IDE that can also be used for local debugging.
- http://hapdebugger.sourceforge.net/