UnEmployed
- Follows the lives of two unemployed roommates and their hard-working neighbor. By Matt Steen.
- http://www.liquitechdesign.com/unemployedcomics/

Uni
- Original comic strip featuring a group of dysfunctional British students.
- http://uni.comicgenesis.com/

The Underground
- Online comic strip by Jeff Russell and Matt Green, about the writers of an unofficial high-school newspaper.
- http://underground.comicgenesis.com/

Ubigod's Hurricane
- Tales and travels of an existential beat superhero and his ex-roommates.
- http://ubigod.comicgenesis.com/

Unripe
- A funny web cartoon that gives a nod to the humor inherent in a complex age.
- http://www.unripe.com/

Utoons
- Cartoons of political humor and life on the Weird Wide Web. By Dan Youra.
- http://utoons.blogharbor.com/

Ugly Hill
- Organized by date and storylines. By Paul Southworth.
- http://www.uglyhill.com/

Unspeakable Vault
- A series based on H.P. Lovecraft's work.
- http://www.macguff.fr/goomi/unspeakable/home.html

United Statements
- Daily panel cartoons by Al Kratzer about the maddening aspects of daily life in America (talk about a wide subject). With a gallery, animated gifs and specials on New Jersey.
- http://www.unitedstatements.com/

Underworld
- Weekly humor strip by Kaz, about sordid doings in a surreal city.
- http://www.kazunderworld.com/

The Unions
- Humorous comic strip. By Earl Ma.
- http://www.theunions.com

Urban Dragons
- Ever wonder what happened to dragons? They're still around; only they've adapted to living in a crowded world. By C. S. McDonald and Sandy Turner.
- http://www.urbandragons.com

Untitled Again
- The story of a college art student who discovers that whatever he draws, comes to life. By Paul Roustan.
- http://untitledagain.keenspace.com

User Friendly
- Comic strip about the Internet and hi-tech business in general. By Illiad. Includes wallpaper and startup screens to download, character profiles and an archive.
- http://www.userfriendly.org/