Small Market Sports
- Weekly sports themed comic strip. Features downloads, an archive and a forum.
- http://www.smallmarketsports.com/

Serram
- About a team in a biotech company that is assigned to hunt and capture mutants and monsters.
- http://www.serram.com/

Sun Fun Cartoons
- An archive from a British newspaper called The Sun, containing Hagar the Horrible, George & Lynne, Sun Fun and political cartoons.
- http://sunfun.net-freaks.com/sunfun/

Shadensmilen
- Showcases the malicious glee experienced upon viewing the misfortune of a happy face.
- http://www.shadensmilen.com/

Slowpoke
- Weekly political cartoon by Jen Sorensen, appearing in alternative newspapers around the country.
- http://www.slowpokecomics.com/

Stick Figure Art
- Daily art since 1998. Organized by month and themes.
- http://incomplete.net

Suburban Jungle
- The life, loves, and career of aspiring supermodel and ferocious predator, Tiffany Tiger. By John "the Gneech" Robey.
- http://www.suburbanjungle.com/

Stick Suicides
- Starring a character called Dopee who occasionally kills himself in a funny fashion.
- http://freewebs.com/sticksuicides/

Syntax Comics
- Humorous strip by artist/author Owanno Megumi.
- http://syntaxcomics.comicgenesis.com/

Stickman Limited
- Comics featuring Stickman Limited and Alabama Bones. Good humor. Bad art.
- http://stickmanltd.comicgenesis.com/

Steverino
- Steverino and his friends go about their daily lives. Includes archive, artist information and character profiles.
- http://steverino.comicgenesis.com/

Soda Venture
- A computer graphic comic by Jacob Gray - includes an archive and character profiles
- http://sodaventure.comicgenesis.com/

Snowball In Hell
- An innocent six-year-old girl and the Demon of Undercooked Pasta embark on a quest through the nether realms. By Kyle Burles and Mike Rieger.
- http://snowball.comicgenesis.com/

Smapdi
- An online comic about a bunch of friends trying their best not to kill each other.
- http://smapdi.comicgenesis.com/

Situation Nowhere
- The harrowing tale of a boy with no last name, lost in a suburban hell with only his attractive yet sexually non-threatening side kick to help him, in a loosely-reality-based comic strip, by Joe.
- http://situationnowhere.comicgenesis.com/

Sentient Thirty-Nine Weirdworks
- Illustrated selections from the Journals of Lado Perapek, who crossed two thirds of the known galaxy in sixty years.
- http://sentient39.comicgenesis.com/

Story Minute
- Minute stories by Carol Lay, on Salon.com.
- http://dir.salon.com/topics/carol_lay/index.html

Spanky the Monkey
- Spanky is an online comic strip about a primate lost in a world gone bananas.
- http://www.spankythemonkey.nl

Simulated Comic Product
- Weekly cartoon by Kevin Forbes.
- http://comics.thekrf.com/

Strip For Me
- Douglas Noble and his comic strips, including Strip For Me, borders, the devil in eden and more.
- http://www.strip-for-me.com/

Field of Sheep
- Features a collection of sheep cartoons doodles.
- http://www.oakleigh.f2s.com/fieldofsheep/

Snopple
- A place where sarcasm goes so very wrong.
- http://www.snopple.co.uk/

Surliness.com
- About I.T workers in college. Features a gallery and a forum.
- http://www.surliness.com/

Steve & Bob
- The adventures of a dog and a mouse. By Mike Georgiou.
- http://www.stevebob.com/

Super Phil
- Comic strip about the adventures of a super hero school boy and his friends.
- http://www.superphil.com/

Savage Chickens
- Cartoons on sticky notes. By Doug Savage.
- http://www.savagechickens.com/

Soup
- A fantasy webcomic about gods, heroes, monsters, and soup.
- http://www.soupcomic.com/

Scrolling Blackout
- Takes place at a college, featuring conspiracies, mind games, and a French exchange student who dresses like it's the 70's... the 1870s.
- http://fennec.homedns.org/

Savingjacksbrain.com
- Home of the college and political humor-themed comic strip. By Zach Martz.
- http://www.savingjacksbrain.com/

Sage and Sid
- Political cartoons and other illustrations by Richard A. Taylor.
- http://www.sageandsid.com/

Staccato
- A post-graduate hippo, three college roommates, a clinically depressed basketball on Prozac who plays GameCube, and a 90MHz server bent on enslaving humanity. By Shawn Handyside.
- http://www.staccatocomic.com/

Stivers, Mark
- The cartoonist features an archive and is a piano tuner too. Features original songs and a blog.
- http://www.markstivers.com/

Shit Happens
- The misadventures of two losers. Art, About, and Archives.
- http://www.raincannon.com/

Station V3
- About life on a seldom-used rest stop and refueling station in a distant solar system.
- http://stationv3.keenspace.com/

School Spirit
- The comic misadventures of Casper, Cody and Co. Join them as they fumble through grade five.
- http://schoolspirit.comicgenesis.com/

Severe Boredom
- Based on an extra-curricular project of two High School friends.
- http://www.severeboredom.com/

Sonic Comic
- Sprite webcomics based on the popular Sega video games.
- http://www.soniccomic.com/

Syntax Errors Comic Strips
- A 3D comic strip about technology and pop culture as seen through the eyes of observant and sarcastic kids.
- http://www.syntaxerrorscomics.com/

The Secret Life of Nick
- The adventures of Nick and his housemate.
- http://www.darkris.com/secretlife/

The Strip Club
- Parodies of popular comic strips.
- http://www.freewebs.com/thestripclub/

Section 54
- Echoing the comedy value of every day life, with a satirical edge.
- http://www.section54.com/

Swine Song Comics
- Diverse story and artwork styles by Colorado-based creator Robert Elrod.
- http://www.swinesongcomics.com/

Student Ghetto
- An archive of Michigan State University's popular comic strip. The origin of the comic strip 'Bachelor Party'.
- http://snaa.statenews.com/plugin.php?plug=gallery&start=index&op=viewalbum&album=45&offset=11&page=7&albumstart=322&albumpage=4&nested=

Saturday Morning Breakfast Cereal
- A collection of bizarre humor.
- http://www.smbc-comics.com/

Savvie and Lacey
- A gentle, humorous treatment of an "adult" topic: BDSM.
- http://www.savvieandlacey.com/

Scribble Cartoon
- Straight from the warped imagination of underground cartoonist, Josh Hara.
- http://www.scribblecartoon.com/